Document Detail


Evidence of muscarinic receptor subtypes in airway smooth muscle of normal volunteers and of chronic obstructive pulmonary disease patients.
MedLine Citation:
PMID:  2707927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since there have been only a few studies on muscarinic receptor subtypes in airway smooth muscle, the effect was investigated of pirenzepine on airways of patients with chronic obstructive pulmonary disease (COPD) and the functional responses compared from these patients with those from healthy subjects. Our data demonstrated that the therapy with pirenzepine significantly improved ventilatory function in patients with COPD. The data also suggested that this drug exerts its action on small airways, but not larger airways in normal subjects. It is possible that in healthy human beings pirenzepine produces mild bronchodilation by means of a vagal efferent blockade, while in patients with COPD, it may be effective because it not only decreases the activity of the vagal efferent pathway, but also decreases the sensitivity of vagal sensory endings and causes a vagal afferent blockade.
Authors:
M Cazzola; M G Matera; G D'Amato; D De Santis; S Maione; M Lisa; M L Cenicola; E Marmo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  9     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, 1st Faculty of Medicine and Surgery, University of Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Atropine / pharmacology*
Forced Expiratory Volume
Humans
Lung Diseases, Obstructive
Muscle, Smooth / drug effects*
Piperidines / pharmacology*
Pirenzepine / pharmacology*
Receptors, Muscarinic / physiology*
Respiratory Muscles / drug effects
Chemical
Reg. No./Substance:
0/Piperidines; 0/Receptors, Muscarinic; 28797-61-7/Pirenzepine; 51-55-8/Atropine; 81405-11-0/4-diphenylacetoxy-1,1-dimethylpiperidinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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