| Evidence for motivational effects elicited by activation of GABA-A or dopamine receptors in the nucleus accumbens shell. | |
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MedLine Citation:
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PMID: 20598739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microinjections of the inhibitory GABA-A receptor agonist muscimol into the shell region of the nucleus accumbens (AcbSh) have been reported to induce large increases in food intake, but the effect of these injections on motivational processes is less clear. In the current study, bilateral injections of saline, muscimol (50ng/side) or d-amphetamine (10mug/side) were made into the AcbSh of rats trained to lever press on a progressive ratio schedule for food reward. Injections of both muscimol and amphetamine were found to produce a large increase in the breaking point relative to saline injections. This result suggests that inactivation of the AcbSh does not simply drive ingestive behavior, but also affects motivational processes assessed by the progressive ratio schedule. Breaking points were also increased by injections of amphetamine into the AcbSh. |
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Authors:
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David Wirtshafter; Thomas R Stratford |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-06-18 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 96 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-10-28 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 342-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Integrative Neuroscience, Department of Psychology (m/c 285), University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607-7137, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Brain Conditioning, Operant / drug effects Dextroamphetamine / administration & dosage, pharmacology Dopamine Agonists / administration & dosage, pharmacology* Dopamine Uptake Inhibitors / administration & dosage, pharmacology Food GABA Agonists / administration & dosage, pharmacology* Injections Male Motivation / drug effects* Muscimol / administration & dosage, pharmacology Nucleus Accumbens / anatomy & histology, drug effects* Rats Rats, Sprague-Dawley Receptors, Dopamine / drug effects* Receptors, GABA-A / drug effects* Reinforcement (Psychology) Reinforcement Schedule |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK071738-01A2/DK/NIDDK NIH HHS; R01 DK071738-02/DK/NIDDK NIH HHS; R01 DK071738-03/DK/NIDDK NIH HHS; R01 DK071738-04/DK/NIDDK NIH HHS; R01DK071738/DK/NIDDK NIH HHS; R03DA020802/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 0/Dopamine Uptake Inhibitors; 0/GABA Agonists; 0/Receptors, Dopamine; 0/Receptors, GABA-A; 2763-96-4/Muscimol; 51-64-9/Dextroamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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