Document Detail

Evidence of morphological and functional abnormalities in the hypothalamus of growth-hormone-deficient children: a combined magnetic resonance imaging and endocrine study.
MedLine Citation:
PMID:  2100274     Owner:  NLM     Status:  MEDLINE    
Fifty-seven children with growth hormone deficiency and 15 healthy age-matched controls were studied by magnetic resonance imaging (MRI). Of the patients, 36 (63%) had isolated GH deficiency (IGHD) and 21 (37%) multiple pituitary hormone deficiency (MPHD). MRI studies showed a marked reduction in pituitary volume in all patients in comparison with normal controls. Moreover, a striking morphological abnormality with the apparent absence of the pituitary stalk and an ectopic posterior pituitary lobe was detected in 34 of the patients (59%). This pituitary stalk abnormality was detected in 95% of the MPHD patients and in 39% of the IGHD patients. All but one of the patients with a normal pituitary stalk had IGHD. Endocrine evaluation showed no correlation with MRI data: in particular patients with an apparent anatomical interruption of the hypothalamic-pituitary axis showed a variety of patterns of hormonal responses. In conclusion, our study shows a high frequency of hypothalamic-pituitary anomalies in patients with GH deficiency, particularly related with MPHD. However, further studies are needed to improve our understanding of the relationship between MRI and endocrine data.
N Bressani; B di Natale; C Pellini; F Triulzi; G Scotti; G Chiumello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  34     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1990  
Date Detail:
Created Date:  1991-08-22     Completed Date:  1991-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Department of Pediatrics, University of Milan, Scientific Institute H San Raffaele, Italy.
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MeSH Terms
Child, Preschool
Growth Hormone / deficiency*
Hydrocortisone / secretion
Hypopituitarism / physiopathology
Hypothalamo-Hypophyseal System / physiopathology*
Hypothalamus / abnormalities,  pathology*
Magnetic Resonance Imaging
Pituitary Hormones / secretion
Thyroid Hormones / secretion
Reg. No./Substance:
0/Pituitary Hormones; 0/Thyroid Hormones; 50-23-7/Hydrocortisone; 9002-72-6/Growth Hormone

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