| Evidence for microvesicular storage and release of glycine in rodent pinealocytes. | |
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MedLine Citation:
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PMID: 11166946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prompted by previous studies suggesting a regulatory role for the inhibitory amino acid gamma-aminobutyric acid (GABA) within the mammalian pineal gland, we carried out a study of rat and gerbil pineal organs to elucidate whether there is evidence for a vesicular storage and release of GABA and/or glycine. Immunohistochemistry revealed the presence of the vesicular inhibitory amino acid transporter in pinealocytes. Moreover, we found that, in addition to glutamate and aspartate, cultured pinealocytes also released glycine upon stimulation by depolarizing concentrations of KCl, whereas the content of GABA in the culture medium did not exceed the detection limit either under control conditions or following KCl application. Therefore, we propose that glycine is a further component of the paracrine signaling system within the pineal organ which is based on the compartment of synaptic-like microvesicles (SLMVs) inside pinealocytes. |
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Authors:
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P Redecker; H Pabst; W Löscher; S Steinlechner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 299 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 93-6 Citation Subset: IM |
Affiliation:
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Medizinische Hochschule Hannover, Abt. Anatomie 1, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. redecker.peter@mh-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Transport Systems* Animals Aspartic Acid / metabolism, secretion Carrier Proteins / metabolism* Cells, Cultured / drug effects, metabolism, secretion Gerbillinae Glutamic Acid / metabolism, secretion Glycine / metabolism, secretion* Immunohistochemistry Microscopy, Electron Pineal Gland / metabolism, secretion*, ultrastructure Potassium Chloride / pharmacology Rats Rats, Wistar Secretory Vesicles / metabolism, secretion*, ultrastructure Vesicular Inhibitory Amino Acid Transport Proteins Vesicular Transport Proteins* gamma-Aminobutyric Acid / metabolism, secretion |
| Chemical | |
Reg. No./Substance:
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0/Amino Acid Transport Systems; 0/Carrier Proteins; 0/Vesicular Inhibitory Amino Acid Transport Proteins; 0/Vesicular Transport Proteins; 0/Viaat protein, rat; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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