| Evidence for "memory" of cervical stimulation for the promotion of pregnancy in rats. | |
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MedLine Citation:
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PMID: 2328968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Successful pregnancy in the female rat depends upon two sets of physiological events: (1) transport of gametes (sperm and egg) through the reproductive tract so that fertilization can be effected and (2) establishment of an appropriate hormonal environment (progestational state) so that the fertilized egg can implant in the uterus and be maintained during subsequent gestation. This study highlights the independence of the mechanisms controlling the gametic and hormonal aspects of pregnancy by temporally separating the introduction of sperm into the female from the stimulation that triggers the progestational hormonal response. The progestational state was initiated by electrical stimulation of the cervix, and sperm was introduced directly into the uterus by artificial insemination. Although these two events were separated by up to 3 days, pregnancy could ensue. Cervical stimulation, normally a consequence of male intromission behavior, establishes a condition in the central nervous system, a "memory" that signals the probable induction of pregnancy. Without this "memory," animals with a short estrous cycle would continue to cycle after mating, thereby producing a hormonal environment incompatible with implantation. The "memory" is manifested by daily surges of prolactin irrespective of fertilization. This is the first physiological demonstration that a "memory" of cervical stimulation can be called upon to support a viable pregnancy. |
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Authors:
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J Terkel; J A Witcher; N T Adler |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hormones and behavior Volume: 24 ISSN: 0018-506X ISO Abbreviation: Horm Behav Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-05-31 Completed Date: 1990-05-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 40-9 Citation Subset: IM |
Affiliation:
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Department of Zoology, Tel Aviv University, Ramat Aviv, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervix Uteri / physiology Copulation / physiology* Estrus / physiology Female Fertilization / physiology* Ovulation / physiology Pregnancy Pregnancy, Animal / physiology* Progesterone / physiology* Prolactin / blood Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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HD04522/HD/NICHD NIH HHS; RR07083-21/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-83-0/Progesterone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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