Document Detail


Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders.
MedLine Citation:
PMID:  21558221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most extensive regenerative ability in adult vertebrates is found in the salamanders. Although it is often suggested that regeneration is an ancestral property for vertebrates, our studies on the cell-surface three-finger-protein Prod 1 provide clear evidence for the importance of local evolution of limb regeneration in salamanders. Prod 1 is implicated in both patterning and growth in the regeneration of limbs. It interacts with well-conserved proteins such as the epidermal growth-factor receptor and the anterior gradient protein that are widely expressed in phylogeny. A detailed analysis of the structure and sequence of Prod 1 in relation to other vertebrate three-finger proteins in mammals and zebra fish supports the view that it is a salamander-specific protein. This is the first example of a taxon-specific protein that is clearly implicated in the mechanisms of regeneration. We propose the hypothesis that regeneration depends on the activity of taxon-specific components in orchestrating a cellular machinery that is extensively conserved between regenerating and non-regenerating taxa. This hypothesis has significant implications for our outlook on regeneration in vertebrates, as well as for the strategies employed in extending regenerative ability in mammals.
Authors:
A Acely Garza-Garcia; Paul C Driscoll; Jeremy P Brockes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-04-21
Journal Detail:
Title:  Integrative and comparative biology     Volume:  50     ISSN:  1557-7023     ISO Abbreviation:  Integr. Comp. Biol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-09-29     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101152341     Medline TA:  Integr Comp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  528-35     Citation Subset:  IM    
Copyright Information:
© The Author 2010. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Evolution*
Extremities / growth & development*
Gene Expression Regulation, Developmental / physiology
Intercellular Signaling Peptides and Proteins / genetics,  physiology
Phylogeny
Regeneration / physiology*
Signal Transduction / physiology
Urodela / growth & development,  physiology*
Grant Support
ID/Acronym/Agency:
G0600229//Medical Research Council; MC_U117574559//Medical Research Council; U117574559//Medical Research Council
Chemical
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins

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