Document Detail


Evidence of a kallikrein inhibitor in human kidney. A new ring of the kallikrein-renin-angiotensin-aldosterone chain.
MedLine Citation:
PMID:  9128066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By means of immunohistochemical reactions, the authors proved the inhibitor II-related immunoreactivity in distal convoluted tubules of human kidney. A sharp inhibitor II-related immunoreactivity was also present in the blood vessels' wall. On the contrary, in the wall of proximal tubules and glomeruli only low reactivity was found. The demonstration of an inhibitor II-related immunoreactivity in the distal convoluted tubules and vessels of human kidney represents a strong evidence that an inhibitor of kallikrein exists and acts also in humans as an important key in the kallikrein-renin-angiotensin-aldosterone chain and hitherto confirms the experimental data of the literature. The proved inhibitor in the human kidney may intervene in the modulation of the kallikrein-kinin system and thus represents a key role in the intrarenal mechanisms related to the blood flow and arterial pressure regulation.
Authors:
L Malinovsky; V D'Andrea; V Malinovska; D Cavallotti; F Santoni; M Belli; C Cavallotti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recenti progressi in medicina     Volume:  88     ISSN:  0034-1193     ISO Abbreviation:  Recenti Prog Med     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-04     Completed Date:  1997-06-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401271     Medline TA:  Recenti Prog Med     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Affiliation:
3a Cattedra di Anatomia, Università La Sapienza Roma.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Humans
Hypertension / physiopathology*
Immunohistochemistry
Kallikreins / antagonists & inhibitors*,  physiology*
Kidney / chemistry*
Kidney Tubules / chemistry
Renin-Angiotensin System / physiology*
Chemical
Reg. No./Substance:
EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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