Document Detail

Evidence of a kallikrein inhibitor in human kidney. A new ring of the kallikrein-renin-angiotensin-aldosterone chain.
MedLine Citation:
PMID:  9128066     Owner:  NLM     Status:  MEDLINE    
By means of immunohistochemical reactions, the authors proved the inhibitor II-related immunoreactivity in distal convoluted tubules of human kidney. A sharp inhibitor II-related immunoreactivity was also present in the blood vessels' wall. On the contrary, in the wall of proximal tubules and glomeruli only low reactivity was found. The demonstration of an inhibitor II-related immunoreactivity in the distal convoluted tubules and vessels of human kidney represents a strong evidence that an inhibitor of kallikrein exists and acts also in humans as an important key in the kallikrein-renin-angiotensin-aldosterone chain and hitherto confirms the experimental data of the literature. The proved inhibitor in the human kidney may intervene in the modulation of the kallikrein-kinin system and thus represents a key role in the intrarenal mechanisms related to the blood flow and arterial pressure regulation.
L Malinovsky; V D'Andrea; V Malinovska; D Cavallotti; F Santoni; M Belli; C Cavallotti
Related Documents :
6957666 - Tubuloglomerular feedback in juxtamedullary nephrons.
9592596 - Liu-wei-dihuang: a study by pulse analysis.
3373646 - Borreliosis in free-ranging black bears from wisconsin.
1330986 - Synthesis, characterization and biodistribution of the cationic technetium(ii) 1,10-phe...
8087236 - Oxygen carriers and transfusion medicine.
23027636 - Mechanics of the foot part 2: a coupled solid-fluid model to investigate blood transpor...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recenti progressi in medicina     Volume:  88     ISSN:  0034-1193     ISO Abbreviation:  Recenti Prog Med     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-04     Completed Date:  1997-06-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401271     Medline TA:  Recenti Prog Med     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
3a Cattedra di Anatomia, Università La Sapienza Roma.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Hypertension / physiopathology*
Kallikreins / antagonists & inhibitors*,  physiology*
Kidney / chemistry*
Kidney Tubules / chemistry
Renin-Angiotensin System / physiology*
Reg. No./Substance:
EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lectin-binding glycoconjugates in the subfornical organ of the rat.
Next Document:  A systematic approach to the solid-phase synthesis of linear and cyclic pseudopeptide libraries cont...