Document Detail

Evidence for the involvement of cannabinoid receptors' polymorphisms in the pathophysiology of human diseases.
MedLine Citation:
PMID:  23293857     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Considerable progress has been made, over the last years, in understanding the role of the endocannabinoid system (ES) in regard to its role in a variety of physiological processes including nociception (pain-sensation), appetite, lipid metabolism, gastrointestinal motility, cardiovascular modulation, motor activity, and memory. Furthermore, ES is strongly associated with human behavior and the skeletal ES is of major importance. ES is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids) and proteins responsible for their metabolism.
AREAS COVERED: To summarize and present all the existing literature that associate CB receptors' polymorphisms with behavior and disease in different populations, as well as its possible therapeutic perspectives. A literature review presenting the most recent data in terms of ES and the latest knowledge regarding the involvement of genetic polymorphisms of cannabinoid receptors in a variety of human diseases and psychiatric and neurological disorders.
EXPERT OPINION: The ES is an emerging target for drug discovery, because it is involved in the regulation of many cellular and physiological functions. The modulation of the ES by selective agonists or antagonists may hold tremendous therapeutic potential in various conditions mentioned in this review. However, further information is still required before the ES is completely comprehended.
Ioanna Vasileiou; Georgia Fotopoulou; Marina Matzourani; Efstratios Patsouris; Stamatios Theocharis
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-08
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  17     ISSN:  1744-7631     ISO Abbreviation:  Expert Opin. Ther. Targets     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-08-28     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-77     Citation Subset:  IM    
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias street, GR11527, Goudi, Athens, Greece.
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MeSH Terms
Autoimmune Diseases / genetics,  metabolism
Genetic Association Studies
Mental Disorders / genetics*,  metabolism
Migraine Disorders / genetics,  metabolism
Obesity / genetics*,  metabolism
Osteoporosis / genetics,  metabolism
Polymorphism, Genetic*
Receptors, Cannabinoid / genetics*,  metabolism
Substance-Related Disorders / genetics,  metabolism
Reg. No./Substance:
0/Receptors, Cannabinoid

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