Document Detail

Evidence for invasion of a human oral cell line by Actinobacillus actinomycetemcomitans.
MedLine Citation:
PMID:  1855989     Owner:  NLM     Status:  MEDLINE    
Actinobacillus actinomycetemcomitans, an oral bacterial species associated with periodontal disease, was found to invade human cell lines. Invasion was demonstrated by recovery of viable organisms from gentamicin-treated KB cell monolayers and by light and electron microscopy. Internalization occurred through a cytochalasin D-sensitive process. Invasion efficiencies of some A. actinomycetemcomitans strains were comparable to those of invasive members of the family Enterobacteriaceae. Differences in invasiveness were correlated with bacterial colonial morphology. Smooth variants invaded more proficiently than rough variants. A. actinomycetemcomitans can undergo a smooth-to-rough colonial morphology shift which results in the loss of invasiveness. Coordinated regulation of genes involved in the rough-to-smooth phenotypic transitions may play a role in the episodic nature of periodontal disease.
D H Meyer; P K Sreenivasan; P M Fives-Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  59     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-23     Completed Date:  1991-08-23     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2719-26     Citation Subset:  IM    
Department of Microbiology and Molecular Genetics, College of Medicine, University of Vermont, Burlington 05405.
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MeSH Terms
Actinobacillus / drug effects,  pathogenicity*,  ultrastructure
Cell Line
Cycloheximide / pharmacology
Cytochalasin D / pharmacology
Gentamicins / pharmacology
Microscopy, Electron
Mouth Neoplasms
Tumor Cells, Cultured
Reg. No./Substance:
0/Gentamicins; 22144-77-0/Cytochalasin D; 66-81-9/Cycloheximide

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