| Evidence of an intrinsic sinus node abnormality in patients with postural tachycardia syndrome. | |
| | |
MedLine Citation:
|
PMID: 11888028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine whether an intrinsic sinus node abnormality is involved in the pathophysiology of the postural tachycardia syndrome (POTS). SUBJECTS, PATIENTS, AND METHODS: In this prospective study, we compared the relationship between P-wave axis (PWA) and heart rate (HR) in 11 healthy controls and 14 patients with POTS by obtaining 12-lead electrocardiographic recordings during supine rest and during gradual head-up tilt. The HR of controls was titrated with isoproterenol infusion to match the HR of patients. The PWA was compared at different HR levels, and the relationship between HR and PWA was assessed for patients and controls. Primary end points were the PWA-HR relationship in healthy controls, comparison of these data with data from patients with POTS as a group, and identification of a possible subgroup of patients with POTS with irregular PWA-HR relationship. RESULTS: The PWA increased with increasing HR following a similar logarithmic trendline in both groups. The PWA of patients was significantly lower at the lowest comparable HR level but not different at faster HR levels. Three patients (21%) had a clearly abnormal HR-PWA relationship with substantial shift toward lower PWA. CONCLUSIONS: Our data support the hypothesis of a primary sinus node abnormality in a subset of patients with POTS. The ability to identify patients with primary sinus node abnormality may have important therapeutic implications. |
| | |
Authors:
|
Wolfgang Singer; Win-Kuang Shen; Tonette L Opfer-Gehrking; Benjamin R McPhee; Max J Hilz; Phillip A Low |
Related Documents
:
|
872318 - The determinants of atrioventricular nodal re-entrance with premature atrial stimulatio... 19717348 - Upgrade and de novo cardiac resynchronization therapy: impact of paced or intrinsic qrs... 9272518 - Vdd pacing in children with congenital complete heart block: advantages of a single pas... 9583278 - Structural characteristics of koch's triangle in patients with atrioventricular node re... 8429318 - Antithrombotic therapy in acute ischaemic stroke: an overview of the completed randomis... 15877668 - Qtc dispersion in haemodialysis patients with cardiac complications. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Mayo Clinic proceedings. Mayo Clinic Volume: 77 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-03-12 Completed Date: 2002-03-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: United States |
Other Details:
|
Languages: eng Pagination: 246-52 Citation Subset: AIM; IM; S |
Affiliation:
|
Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cardiotonic Agents / diagnostic use Case-Control Studies Diagnosis, Differential Electrocardiography Female Head-Down Tilt Heart Rate Humans Hypotension, Orthostatic / diagnosis*, etiology*, physiopathology Isoproterenol / diagnostic use Male Posture* Prospective Studies Supine Position Syndrome Tachycardia / diagnosis*, etiology*, physiopathology Tachycardia, Sinus / complications*, diagnosis*, physiopathology Tilt-Table Test |
| Grant Support | |
ID/Acronym/Agency:
|
M01 RR00585/RR/NCRR NIH HHS; P01 NS32352/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of parental vaccination reports with measles, mumps, and rubella protective antibody lev...
Next Document: Diagnosis and treatment of migraine.