Document Detail

Evidence for intracellular generation of angiotensin II in rat juxtaglomerular cells.
MedLine Citation:
PMID:  9498824     Owner:  NLM     Status:  MEDLINE    
The formation of the vasoactive peptide angiotensin II (AII) is dependent on the sequential action of two enzymes, renin and angiotensin converting enzyme (ACE), on the substrate angiotensinogen. Although the renin-producing cells of the kidney do not express angiotensinogen, they contain large amounts of AII in the same storage granules that contain renin. When renin expression is suppressed in these cells, AII also disappears. In the current study, we have tested whether the renin-associated disappearance of AII in renal juxtaglomerular (JG) cells is due to a renin-dependent down-regulation of granule biosynthesis and whether receptor-mediated internalization of AII could account for its concentration in these cells. Our results support a model whereby AII peptides are generated within JG cells, presumably by a mechanism which involves the action of endogenous renin on internalized, exogenous angiotensinogen.
C Mercure; D Ramla; R Garcia; G Thibault; C F Deschepper; T L Reudelhuber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  422     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Que., Canada.
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MeSH Terms
Angiotensin II / biosynthesis*
Juxtaglomerular Apparatus / cytology,  metabolism*,  ultrastructure
Rats, Sprague-Dawley
Receptors, Angiotensin / antagonists & inhibitors,  metabolism
Renin / antagonists & inhibitors,  metabolism
Reg. No./Substance:
0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; EC

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