Document Detail

Evidence for the inheritance of silver-stained nucleolus organizer regions.
MedLine Citation:
PMID:  147853     Owner:  NLM     Status:  MEDLINE    
The inheritance of nucleolus organizer regions (NORs) was investigated by examining the degree of silver-staining in individual acrocentric chromosomes in two successive generations. The study was undertaken in six Down's syndrome children and their respective parents. Quinacrine fluorescent polymorphisms were used to identify individual acrocentrics and to determine which of the child's acrocentrics were informative as to parental homologue of origin. Of the 66 acrocentrics in the six children, 31 were informative. The correlation between the degree of silver=staining in the child's chromosomes and the respective parental chromosomes of origin was highly significant (P less than 0.001), with a correlation coefficient of 0.90. The results suggest that the degree of Ag-AS staining is characteristic for a particular chromosome and that this characteristic is an inherited property.
V D Marković; R G Worton; J M Berg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  41     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
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MeSH Terms
Cell Nucleolus*
Down Syndrome / genetics
Polymorphism, Genetic
RNA, Ribosomal*
Reg. No./Substance:
0/RNA, Ribosomal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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