Document Detail

Evidence for influenza virus CNS invasion along the olfactory route in an immunocompromised infant.
MedLine Citation:
PMID:  24550441     Owner:  NLM     Status:  Publisher    
Central nervous system (CNS) disease is the most common extra-respiratory complication of influenza in humans. However, the pathogenesis, including the route of virus entry, is largely unknown. Here we present for the first time evidence for influenza virus entry into the CNS via the olfactory route in an immune-compromised infant. Since the nasal cavity is a primary site of influenza virus replication and is directly connected to the CNS via the olfactory nerve, these results imply that influenza virus invasion of the CNS may occur more often than hitherto suspected.
Debby van Riel; Lonneke M Leijten; Rob M Verdijk; Corine Geurtsvankessel; Erhard van der Vries; Annemarie M C van Rossum; Ab D M E Osterhaus; Thijs Kuiken
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-18
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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