| Evidence for infection of the human embryo with adeno-associated virus in pregnancy. | |
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MedLine Citation:
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PMID: 10469719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous reports have demonstrated the presence of DNA of the human helper virus-dependent adeno-associated parvovirus (AAV) in uterine tissue and curettage material from early miscarriage. To examine infection of embryonic tissue during pregnancy, amnion fluids were analysed for the presence of AAV. Using polymerase chain reaction, AAV DNA was detected in 64 out of 238 DNA samples extracted from amnion cells. DNA of helper viruses were found in 12% (papillomavirus) and 18% (cytomegalovirus) of the samples (double infections with AAV in eight and nine cases, respectively). Furthermore, infectious AAV virions were found in 13 out of 43 AAV DNA-containing samples. In mothers with AAV DNA-positive amnion fluids, premature amniorrhexis and premature labour occurred significantly more frequently (P < 0.001). Using an immunofluorescence assay, 24% of newborn sera (unrelated to the amnion fluid samples) were found to contain IgM antibodies to AAV, in most cases paralleled by IgM antibodies in the mother's sera. The data demonstrate that AAV infection can occur in utero at early and at late stages of pregnancy. The observed complications at delivery should encourage studies to clarify possible pathological consequences of AAV infection in pregnancy and a possible latent infection of the fetus. |
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Authors:
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T Burguete; M Rabreau; M Fontanges-Darriet; E Roset; H D Hager; A Köppel; P Bischof; J R Schlehofer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 14 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2396-401 Citation Subset: IM |
Affiliation:
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Deutsches Krebsforschungszentrum (DKFZ), Angewandte Tumorvirologie, Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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virology Antibodies, Viral / blood DNA, Viral / analysis Dependovirus* / isolation & purification Female Fetal Diseases / virology* Fluorescent Antibody Technique Gestational Age Humans Immunoglobulin M / blood Infant, Newborn Obstetric Labor, Premature / virology Parvoviridae Infections* Polymerase Chain Reaction Pregnancy Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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