Document Detail

Evidence for indirect genetic damage as methylation of DNA guanine in response to cytotoxicity.
MedLine Citation:
PMID:  6677451     Owner:  NLM     Status:  MEDLINE    
Administration of hepatotoxic doses of the inorganic carcinogen, hydrazine, to rodents results in the rapid formation of methylguanines in liver DNA, the methyl donor presumably being S-adenosylmethionine. The DNA methylation pattern after hydrazine administration is qualitatively similar to that seen after dimethylnitrosamine administration, and this type of genotoxicity is thought to be part of the initiation process in chemical carcinogenesis. Preliminary evidence suggests that the methylation of liver DNA guanine may be an endogenous response to the cytotoxicity caused by hydrazine rather than due to any intrinsic property of the chemical itself. These investigations represent an approach to the study of the causal role, if any, of toxicity in chemical carcinogenesis.
R C Shank
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Developments in toxicology and environmental science     Volume:  11     ISSN:  0165-2214     ISO Abbreviation:  Dev Toxicol Environ Sci     Publication Date:  1983  
Date Detail:
Created Date:  1984-08-01     Completed Date:  1984-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706742     Medline TA:  Dev Toxicol Environ Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
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MeSH Terms
DNA / metabolism*
Dose-Response Relationship, Drug
Guanine / analogs & derivatives,  metabolism*
Guinea Pigs
Hydrazines / toxicity
Liver / drug effects*,  metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Carcinogens; 0/Hydrazines; 20535-83-5/O-(6)-methylguanine; 578-76-7/7-methylguanine; 73-40-5/Guanine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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