Document Detail

Evidence of increased gluconeogenesis during hemorrhage in fed and 24-hour food-deprived rats.
MedLine Citation:
PMID:  2911109     Owner:  NLM     Status:  MEDLINE    
Food withdrawal 24 hr before hemorrhage has been shown to increase experimental post-hemorrhage mortality, and survival is associated with the degree of hyperglycemia. Lack of hyperglycemic response has been attributed to depleted glycogen reserves after 24-hr food withdrawal. To investigate the effect of short-term food deprivation on glucose metabolism during hemorrhagic stress, glucose production (rate of appearance, Ra), glucose uptake (rate of disappearance, Rd), glucose clearance, and glucose recycling were investigated in fed and 24-hr food-deprived rats under basal conditions, and during hemorrhagic hypotension using 3-H3-U-C14-glucose. During hemorrhage, blood glucose levels were higher in fed rats. Hemorrhage induced a decrease in glucose clearance irrespective of nutritional state in both 24-hr starved animals and rats in the postprandial state. Calculated glucose recycling increased in both groups after hemorrhage. The results indicate that hemorrhagic stress induces a rapid increase in gluconeogenesis, as reflected by increased glucose recycling.
O Ljungqvist; A Khan; J Ware
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  29     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-22     Completed Date:  1989-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  AIM; IM    
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Blood Glucose / metabolism
Blood Pressure
Food Deprivation / physiology*
Hemorrhage / blood,  metabolism*,  physiopathology
Lactates / blood
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Glucose; 0/Lactates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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