Document Detail

Evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty acids in the intact cell.
MedLine Citation:
PMID:  7893739     Owner:  NLM     Status:  MEDLINE    
Preincubation of isolated rat hepatocytes with desferrioxamine or o-phenanthroline, two iron-specific chelators, strongly suppressed the CO2-production from the alpha-oxidation of 3-methylmargaric acid, whereas the beta-oxidation of 2-methylpalmitic acid, palmitic acid, trihydroxycoprostanic acid and the conversion of formic acid to CO2 were not affected. When, after the initial preincubation with the chelators and prior to the addition of 3-methylmargaric acid, iron-saturated transferrin and Fe3+ were added, a partial restitution of the CO2-production rates was obtained. These facts provide further evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty acids.
K Croes; M Casteels; P P van Veldhoven; G P Mannaerts
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1255     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM    
Katholieke Universiteit Leuven, Afdeling Farmacologie, Belgium.
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MeSH Terms
Cells, Cultured
Cholestanols / metabolism
Fatty Acids / metabolism*
Iron / pharmacology
Iron Chelating Agents / pharmacology*
Liver / drug effects*,  metabolism
Oxidation-Reduction / drug effects
Palmitic Acid
Palmitic Acids / metabolism
Rats, Wistar
Reg. No./Substance:
0/Cholestanols; 0/Fatty Acids; 0/Iron Chelating Agents; 0/Palmitic Acids; 27147-71-3/2-methylhexadecanoic acid; 547-98-8/3,7,12-trihydroxycholestan-26-oic acid; 57-10-3/Palmitic Acid; 60787-51-1/3-methylheptadecanoic acid; 7439-89-6/Iron

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