Document Detail

Evidence for impaired physiological decrease in the uteroplacental vascular resistance in pregnant women with familial hypercholesterolemia.
MedLine Citation:
PMID:  18972234     Owner:  NLM     Status:  MEDLINE    
Abnormal hyperlipidemia characterizes pregnancy in familial hypercholesterolemia (FH), and is associated with vascular dysfunction. Hence, we compared blood flow in the feto- and uteroplacental circulation in FH and healthy reference women using Doppler velocimetry. The umbilical artery pulsatility index (PI) at gestational weeks 24 and 36, and the concomitant physiological decrease in PI, was similar in FH (n=10) and the reference group (n=143). The decrease in mean PI of both uterine arteries from week 24 to 36 was significant in the reference group, but not among the FH women. Plasma LDL-cholesterol measured between weeks 24 and 36 was not correlated with the decrease in umbilical PI in the FH group, or with the decrease in umbilical or mean uterine PI in the reference group. We conclude that pregnancy in FH might be associated with attenuated physiological decrease in mean PI of uterine arteries, possibly reflecting increased uteroplacental vascular resistance unrelated to plasma LDL-cholesterol levels.
Janette Khoury; Agot L Amundsen; Serena Tonstad; Tore Henriksen; Leiv Ose; Kjetil Retterstøl; Per O Iversen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  222-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Rikshospitalet University Hospital, Oslo, Norway.
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MeSH Terms
Cholesterol, LDL / blood
Hyperlipoproteinemia Type II / blood,  physiopathology*
Placental Circulation*
Pregnancy Complications / blood,  physiopathology*
Pulsatile Flow
Umbilical Arteries / physiopathology,  ultrasonography
Uterus / blood supply
Vascular Resistance*
Reg. No./Substance:
0/Cholesterol, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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