Document Detail

Evidence of impaired left ventricular systolic function by Doppler myocardial imaging in patients with systemic amyloidosis and no evidence of cardiac involvement by standard two-dimensional and Doppler echocardiography.
MedLine Citation:
PMID:  18359328     Owner:  NLM     Status:  MEDLINE    
We examined the potential role of Doppler myocardial imaging for early detection of systolic dysfunction in patients with systemic amyloidosis (AL) but without evidence of cardiac involvement by standard echocardiography. We identified 42 patients without 2-dimensional echocardiographic or Doppler evidence of cardiac involvement. These patients had normal ventricular wall thickness and normal velocity of the medial mitral annulus. Myocardial images were obtained in these patients and in 32 age- and gender-matched healthy controls. Peak longitudinal systolic tissue velocity (sTVI), systolic strain rate (sSR), and systolic strain (sS) were determined for 16 left ventricular segments. Radial and circumferential sSR and sS were also measured. Compared with controls in this group of patients with AL, peak longitudinal sSR (-1.0 +/- 0.2 vs -1.4 +/- 0.2, p <0.001) and peak longitudinal sS (-15.6 +/- 3.3 vs -22.5 +/- 2.0 p <0.001) were significantly decreased. In conclusion, the mean sS from all 6 basal segments, or from all 16 left ventricular segments differentiated patients with AL with normal echocardiography from controls, with similar accuracy for the mean sSR from the 6 basal segments. This distinction was not apparent from peak longitudinal sTVI or from radial or circumferential sSI or sSR.
Diego Bellavia; Patricia A Pellikka; Theodore P Abraham; Ghormallah B Al-Zahrani; Angela Dispenzieri; Jae K Oh; Kent R Bailey; Christina M Wood; Martha Q Lacy; Chinami Miyazaki; Fletcher A Miller
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-01
Journal Detail:
Title:  The American journal of cardiology     Volume:  101     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1039-45     Citation Subset:  AIM; IM    
Cardiovascular Division, Mayo Clinic and Foundation, Rochester, MN, USA.
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MeSH Terms
Amyloidosis / complications,  ultrasonography*
Case-Control Studies
Echocardiography, Doppler / methods*
Middle Aged
Ventricular Dysfunction, Left / etiology,  ultrasonography*
Ventricular Function, Left*

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