Document Detail

Evidence for impaired endothelium dependent vasodilation in experimental left ventricular dysfunction.
MedLine Citation:
PMID:  7820949     Owner:  NLM     Status:  MEDLINE    
1. The full range of vascular reactivity was investigated in the hindlimb circulation of conscious, autonomically blocked rabbits with experimental (adriamycin-induced) cardiomyopathy. 2. Adriamycin treatment caused a significant reduction in left ventricular systolic function, as assessed by echocardiography (left ventricular fractional shortening, controls vs adriamycin treatment; 36.7 +/- 1.7% vs 27.3 +/- 2.6%, P < 0.05). 3. Under pharmacological autonomic effector block, the range of the vasodilator response (resistance range, from resting to full vasodilatation) to acetylcholine was reduced by 41% (P < 0.05) and by 37% for adenosine (P < 0.05). Despite these changes the sensitivity (ED50) of the responses were unaltered. 4. The ED50 of constrictor responses to noradrenaline and angiotensin II were similarly unaltered, in conjunction with a non-significant attenuation of the constrictor-response range. 5. These results suggest that in this model of experimental left ventricular dysfunction, the capacity of the hindlimb circulation to respond to regionally infused endothelium dependent vasodilators is attenuated.
D M Kaye; G Jennings; J A Angus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  21     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-16     Completed Date:  1995-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  709-19     Citation Subset:  IM    
Alfred Baker Medical Unit, Baker Medical Research Institute, Melbourne, Australia.
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MeSH Terms
Acetylcholine / pharmacology
Adenosine / pharmacology
Angiotensin II / pharmacology
Autonomic Nerve Block
Hindlimb / blood supply
Injections, Intra-Arterial
Ischemia / physiopathology
Models, Cardiovascular
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Vasoconstriction / drug effects,  physiology*
Vasodilation / drug effects,  physiology*
Ventricular Dysfunction, Left / chemically induced,  physiopathology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 23214-92-8/Doxorubicin; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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