Document Detail


Evidence of immunosuppression in the genetically epilepsy-prone rat.
MedLine Citation:
PMID:  2041456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immune system function was examined in the genetically epilepsy prone (GEPR-9) rat and non-epileptic Sprague-Dawley control rats. Significant decreases in direct and indirect plaque-forming cell responses were observed in GEPR-9 rats immunized with sheep erythrocytes. Serum levels of IgM were also decreased in non-immunized GEPR-9 rats, providing additional evidence of immunosuppression. However, total serum levels of IgG were three-fold greater in GEPR-9 rats compared to control. These results suggest that the nature of the immune system deficit in the GEPR-9 is complex and may involve an active T-cell population stimulating an overproduction of IgG leading to a diminished capacity to respond to new antigen challenges. This immunological defect may underlie the enhanced susceptibility of GEPR-9 rats to infectious agents. The specific cause of this immune dysfunction is not known. Possible etiological factors include a breakdown in the communication between cells within the immune system or an alteration of neuroendocrine modulation of immune responses.
Authors:
R R Rowland; S Tokuda; G K Weiss; D Tso-Olivas; D D Savage
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  48     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1821-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology, University of New Mexico School of Medicine, Albuquerque 87131-5316.
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology
Epilepsy / blood,  genetics,  immunology*
Erythrocyte Transfusion
Hemolytic Plaque Technique
Immune Tolerance / genetics*
Immunocompetence / genetics
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Rats
Rats, Inbred Strains
Sheep
Grant Support
ID/Acronym/Agency:
NS23262/NS/NINDS NIH HHS; NS24008/NS/NINDS NIH HHS; RR08139/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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