Document Detail

Evidence for immune complexes involving anti-lymphocyte antibodies associated with hypocomplementaemia in chronic lymphocytic leukaemia (CLL).
MedLine Citation:
PMID:  136325     Owner:  NLM     Status:  MEDLINE    
Unmeasurable total haemolytic complement (C) was observed in serum of a patient with untreated chronic lymphocytic leukaemia and recurrent non-hereditary angioedema. Analysis of C components immunochemically demonstrated a marked reduction of C1q and C1s inhibitor, undetectable C1r, C1s and an elevated B. Haemolytic C1, C4 and C2 were less than 5 percent of normal, functional C1s inhibitor was absent. Cryoglobulin and C1q precipitins were present in the serum. Of special interest was the presence of high levels of cold-reactive antilymphocyte antibody, determined by both C-dependent cytotoxicity and indirect immunofluorescence. The antibody exhibited specificities for both autologous lymphocytes and lymphocytes from normal donors; cytotoxic activity for autologous leukaemia cells was removed by absorption with normal isologous tonsil lymphocytes. Specific enrichment of this antibody relative to the serum level was demonstrated in the cryoglobulin and its isolated 19S fractions. Free lymphocyte surface antigen was also demonstrated by gel diffusion using specific rabbit antilymphocyte antiserum. These data strongly suggest the presence of pathogenetically significant circulating complexes of lymphocyte surface antigen and specific antibody in certain patients with CLL.
N K Day; J B Winfield; T Gee; R Winchester; H Teshima; H G Kunkel
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  26     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-28     Completed Date:  1977-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
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MeSH Terms
Angioedema / complications
Antigen-Antibody Complex*
Cell Membrane / immunology
Complement System Proteins / deficiency*
Cryoglobulins / analysis
Cytotoxicity Tests, Immunologic
Immune Complex Diseases
Immunoglobulin M / analysis
Leukemia, Lymphoid / complications,  immunology*
Lymphocytes / immunology*
Middle Aged
Reg. No./Substance:
0/Antibodies; 0/Antigen-Antibody Complex; 0/Antigens; 0/Cryoglobulins; 0/Immunoglobulin M; 9007-36-7/Complement System Proteins

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