Document Detail


Evidence for human orosensory (taste?) sensitivity to free fatty acids.
MedLine Citation:
PMID:  17361006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accumulating evidence suggests dietary fatty acids (FAs) may be sensed in the oral cavity. However, the effective cues have not been characterized. In particular, influences from other sensory cues have hampered identification of an independent gustatory contribution. Experiment 1 examined techniques to minimize the formation of FA oxidation products and improve the homogeneity of water/lipid emulsions to be used as stimuli in Experiment 2, a psychophysical study to determine FA detection thresholds in humans. Through sonication of chilled samples held in polypropylene labware and the addition of 0.01% ethylenediaminetetraacetic acid, calcium disodium salt, homogenous emulsions of unoxidized linoleic and oleic FAs were obtained. Spectrophotometric analysis revealed no oxidation product formation over a 24-h period. Coupled with these techniques, a masking approach was used to minimize other sensory cues imparted from linoleic, oleic, and stearic FAs. Concentration ranges from 0.00028% to 5% (w/v) were prepared in mixtures with 5% mineral oil (w/v) and 5% gum acacia (w/v) to mask lubricity and viscosity effects, respectively. Testing was conducted under red light with nares blocked to eliminate visual and olfactory cues. Oral rinses with 20 ppm capsaicin were administered to desensitize participants to selected irritation effects prior to remeasuring linoleic acid detection thresholds. To determine if the effective stimulus was an oxidation product, oxidized linoleic acid was included among the test stimuli. Detection thresholds were obtained using a 3-alternative, forced-choice ascending-concentration presentation procedure. The mean detection threshold for linoleic acid pre-desensitization was 0.034 +/- 0.008%, for linoleic acid post-desensitization was 0.032 +/- 0.007%, for oleic 0.022 +/- 0.003%, for stearic 0.032 +/- 0.005%, and oxidized linoleic 0.025 +/- 0.005%. The results suggest that linoleic, oleic, stearic, and oxidized linoleic acids are detectable in the oral cavity of humans with minimal input from the olfactory, capsaicin, and viscosity-assessing tactile systems.
Authors:
Angela Chalé-Rush; John R Burgess; Richard D Mattes
Related Documents :
12166986 - Differential incorporation of conjugated linoleic acid isomers into egg yolk lipids.
7622416 - Lack of promoting effects of alpha-linolenic, linoleic or palmitic acid on urinary blad...
15218546 - The contribution of uncoupling protein and atp synthase to state 3 respiration in acant...
21702476 - Taste modulating n-(1-methyl-4-oxoimidazolidin-2-ylidene) α-amino acids formed from cr...
6526986 - Transfer of fatty acid across the cat placenta.
1147896 - Some observations on chlorophyll(ide) synthesis by isolated etioplasts.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-03-14
Journal Detail:
Title:  Chemical senses     Volume:  32     ISSN:  0379-864X     ISO Abbreviation:  Chem. Senses     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-07     Completed Date:  2007-07-31     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  423-31     Citation Subset:  IM    
Affiliation:
Department of Foods and Nutrition, Purdue University, Lafayette, IN 47907-1264, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Fatty Acids, Nonesterified / pharmacology*
Female
Humans
Male
Spectrum Analysis / methods
Taste / drug effects*
Grant Support
ID/Acronym/Agency:
DK045294/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway...
Next Document:  Reduced penetrance alleles for Huntington's disease: a multi-centre direct observational study.