Document Detail


Evidence for hormonal inhibition of exocrine pancreatic function by somatostatin 28 in humans.
MedLine Citation:
PMID:  1351858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Somatostatin 28 (S-28), originating in gastrointestinal cells, is secreted into the circulation and increases in humans after ingestion of a mixed meal. To evaluate the possibility that the increased levels of S-28 post cibum might modulate the release of enzymes and bicarbonate from the exocrine pancreas, S-28 was infused intravenously into healthy volunteers to levels seen after food intake. During S-28 infusion, the output of lipase, trypsin, amylase, and bicarbonate stimulated by either exogenous cholecystokinin octapeptide or endogenous signals from intraduodenal administration of tryptophan or a mixture of amino acids was significantly reduced. It is concluded that S-28 released from the gut during food intake modulates pancreatic exocrine function in humans.
Authors:
P Hildebrand; J W Ensinck; K Gyr; S Mossi; J Leuppi; C Eggenberger; C Beglinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  103     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-07-24     Completed Date:  1992-07-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-7     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology, University Hospital, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / pharmacology
Cholecystokinin / blood
Dose-Response Relationship, Drug
Duodenum
Humans
Infusions, Intravenous
Male
Osmolar Concentration
Pancreas / drug effects*,  physiology,  secretion
Perfusion
Somatostatin / blood,  pharmacology*
Somatostatin-28
Tryptophan / pharmacology
Grant Support
ID/Acronym/Agency:
R01-DK4397/DK/NIDDK NIH HHS; RR-37/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 51110-01-1/Somatostatin; 73-22-3/Tryptophan; 75037-27-3/Somatostatin-28; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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