Document Detail


Evidence of high polymeric IgA levels in serum of patients with Berger's disease and its modification with phenytoin treatment.
MedLine Citation:
PMID:  548996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High levels of polymeric IgA were found in the serum of patients with IgA glomerulonephritis. In four of the patients the IgA percentage distribution was established by ultracentrifugation in sucrose density gradients before and after six months of phenytoin treatment. A decrease in polymeric IgA, adopting a pattern similar to the controls, was observed. These findings may have both pathogenic and therapeutic implications.
Authors:
M L Trascasa; J Egido; J Sancho; L Hernando
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  16     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1979  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Centrifugation, Density Gradient
Glomerulonephritis / drug therapy,  immunology*
Humans
Immunoglobulin A*
Molecular Weight
Phenytoin / therapeutic use*
Polymers*
Time Factors
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Polymers; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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