| Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study. | |
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MedLine Citation:
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PMID: 15653258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based upon pharmacological challenge and postmortem studies, schizophrenia has been hypothesized to be caused by decreased glutamatergic neurotransmission. We investigated the glutamatergic neuronal metabolism of the dorsolateral prefrontal cortex with localized 1H magnetic resonance spectroscopy in 18 first-episode patients, 21 chronic patients with schizophrenia, and 21 age-matched controls. Chronic patients had significantly lower levels of glutamate/glutamine (Glx) and N-acetylaspartate (NAA) compared to healthy controls and first-episode patients. Reduced metabolite levels were not correlated with duration of illness or medication. Our results indicate glutamatergic dysfunction in chronic schizophrenia that could be evidence of a progressive brain disorder. |
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Authors:
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Patricia Ohrmann; Ansgar Siegmund; Thomas Suslow; Katharina Spitzberg; Anette Kersting; Volker Arolt; Walter Heindel; Bettina Pfleiderer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Schizophrenia research Volume: 73 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-06-09 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-7 Citation Subset: IM |
Affiliation:
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University of Muenster, Department of Psychiatry, Albert-Schweitzer-Str. 11, Germany. ohrmann@uni-muenster.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives*, metabolism* Chronic Disease Diagnostic and Statistical Manual of Mental Disorders Female Glutamic Acid / metabolism* Glutamine / metabolism* Humans Magnetic Resonance Spectroscopy* Male Neurons / metabolism, physiology* Prefrontal Cortex / metabolism*, physiopathology* Protons / diagnostic use* Schizophrenia / diagnosis, metabolism*, physiopathology* Schizophrenic Psychology Severity of Illness Index Synaptic Transmission / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Protons; 56-84-8/Aspartic Acid; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 997-55-7/N-acetylaspartate |
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