| Evidence for a genetic component in sudden infant death syndrome. | |
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MedLine Citation:
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PMID: 12515435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is increasing evidence that inflammatory responses have been elicited in some Sudden Infant Death Syndrome (SIDS) infants and that these responses are under genetic control. The objective of this study was to investigate the hypothesis that the cytokine responses of SIDS parents (n = 41) differed significantly from control donors (n = 61). Blood samples were stimulated with the staphylococcal toxin TSST-1 and LPS from Eschericia coli and assessed for production of TNF, IL-1, IL-6, IFN and IL-10. In response toTSST-1 (P < 0.02) and LPS (P < 0.002), SIDS parents produced higher levels of IL-1 than the controls. SIDS parents produced higher levels of IFN in response to TSST-1 compared to LPS (P < 0.001) although in response to LPS, the IFN (P = 0.0008) and IL-6 (P < 0.0002) responses of the SIDS parents were lower than those of the controls. For TNF and IL-10, there was little difference between the two groups unless the effect of smoking was considered. As part of this work, a small pilot genotyping study was carried out using DNA from SIDS parents (n = 10), control donors (n = 10) and Bangladeshi subjects (n = 10). An IFN polymorphism (3/3) was found in 40%,15.4% and 0% of donors respectively. Staphylococcal toxins have been identified in SIDS infants therefore this study highlights the importance of assessing IL-1 levels. Determination of cytokine polymorphisms and consideration of interactions between these and environmental factors such as smoking in high, average and low risk ethnic groups will assist in establishing the contribution of these factors to an infant's susceptibility to SIDS. |
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Authors:
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A E Gordon; D A C MacKenzie; O R El Ahmer; O M Al Madani; J M Braun; D M Weir; A Busuttil; C C Blackwell |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Child: care, health and development Volume: 28 Suppl 1 ISSN: 0305-1862 ISO Abbreviation: Child Care Health Dev Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2003-01-07 Completed Date: 2003-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7602632 Medline TA: Child Care Health Dev Country: England |
Other Details:
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Languages: eng Pagination: 27-9 Citation Subset: IM |
Affiliation:
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Medical Microbiology and Forensic Medicine, University of Edinburgh, Edinburgh, UK. a.e.gordon@dundee.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bangladesh Case-Control Studies Cytokines / biosynthesis Female Genetic Predisposition to Disease Genotype Humans Infant Inflammation / blood, complications Interferons / blood, genetics Interleukin-1 / blood, genetics Interleukin-6 / blood, genetics Male Polymorphism, Genetic Sudden Infant Death / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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