Document Detail


Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness: a study of 8- to 18-yr-old twins.
MedLine Citation:
PMID:  11112136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured asthma in the last 12 mo, diagnosed by a respiratory physician at interview; atopy, defined by a positive skin prick test to any of eight common allergens; and bronchial hyperresponsiveness (BHR) to hypertonic saline, in 381 twin pairs aged 8 to 18 yr selected from the Australian Twin Registry-183 monozygous (MZ) and 198 dizygous (DZ). The associations between twins, as measured by an odds ratio, were greater in MZ pairs compared with DZ pairs for asthma: 25.6 (95% confidence interval 11.3- 57.8) versus 1.9 (1.0-3. 5); atopy: 14.6 (7.1-30.1) versus 2.5 (1.4- 4.5); and BHR: 14.1 (6. 4-31.0) versus 4.2 (2.1-8.6) (all p < 0.002). The associations between each pair of traits within an individual were slightly greater than the association between one trait in a twin and the other trait in the cotwin (cross-trait cross-pair) in MZ pairs. Further, the associations in MZ pairs were greater than in DZ pairs (p < 0.05). Under the assumptions of the classic twin model, these data suggest that the strong cross-sectional associations between these three traits are due to an overlap between the genetic factors involved in each of these three traits.
Authors:
J R Clarke; M A Jenkins; J L Hopper; J B Carlin; C Mayne; D G Clayton; M F Dalton; D P Holst; C F Robertson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  162     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-24     Completed Date:  2001-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2188-93     Citation Subset:  AIM; IM    
Affiliation:
Respiratory & Cystic Fibrosis Unit, The Birmingham Children's Hospital NHS Trust, Birmingham, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Asthma / diagnosis,  etiology,  genetics*,  physiopathology
Bronchial Hyperreactivity / diagnosis,  etiology,  genetics*
Bronchial Provocation Tests / statistics & numerical data
Child
Diseases in Twins / diagnosis,  genetics*
Female
Humans
Hypersensitivity, Immediate / diagnosis,  etiology,  genetics*
Male
Odds Ratio
Questionnaires
Skin Tests / statistics & numerical data
Twins, Dizygotic
Twins, Monozygotic
Victoria

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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