Document Detail


Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.
MedLine Citation:
PMID:  9861048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mutations in either of two human presenilin genes (PS1 and PS2) cause Alzheimer's disease. Here we describe genetic and physical interactions between Caenorhabditis elegans SEL-10, a member of the Cdc4p family of proteins, and SEL-12, a C. elegans presenilin. We show that loss of sel-10 activity can suppress the egg-laying defective phenotype associated with reducing sel-12 activity, and that SEL-10 can physically complex with SEL-12. Proteins of the Cdc4p family have been shown to target proteins for ubiquitin-mediated turnover. The functional and physical interaction between sel-10 and sel-12 therefore offers an approach to understanding how presenilin levels are normally regulated.
Authors:
G Wu; E J Hubbard; J K Kitajewski; I Greenwald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-28     Completed Date:  1999-01-28     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15787-91     Citation Subset:  IM    
Affiliation:
Department of Pathology and Center for Reproductive Sciences, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / physiology*
Caenorhabditis elegans Proteins*
Cell Cycle Proteins / chemistry*,  genetics,  physiology*
Cell Line
F-Box Proteins*
Genotype
Helminth Proteins / chemistry*,  genetics,  physiology*
Humans
Membrane Proteins / chemistry*,  genetics,  physiology*
Recombinant Proteins / chemistry,  metabolism
Transfection
Ubiquitin-Protein Ligases*
Grant Support
ID/Acronym/Agency:
NS35556/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Cell Cycle Proteins; 0/F-Box Proteins; 0/Helminth Proteins; 0/Membrane Proteins; 0/Recombinant Proteins; 0/SEL-10 protein, C elegans; 0/SEL-12 protein, C elegans; EC 6.3.2.19/FBXW7 protein, human; EC 6.3.2.19/Ubiquitin-Protein Ligases
Comments/Corrections

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