| Evidence for the formation of a known toxin, p-cresol, from menthofuran. | |
| | |
MedLine Citation:
|
PMID: 2043129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinary metabolites were investigated. Among the several metabolites formed, two of them viz. 4-Hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) were identified. In support of the formation of these metabolites, it has been demonstrated that phenobarbital induced rat liver microsomes readily convert 4-methyl-2-cyclohexenone (V) to 4-hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) in the presence of NADPH and O2. Possible mechanism for the formation of these two metabolites (VII, VIII) from menthofuran (II) has been proposed. |
| | |
Authors:
|
K M Madyastha; C P Raj |
Related Documents
:
|
7093439 - Identification and quantitative determination of m-hydroxyphenylglycol in mammalian urine. 8560469 - Biotransformation of acrolein in rat: excretion of mercapturic acids after inhalation a... 17315539 - Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (pbi) analog (rwj-5... 6746719 - The metabolism of n-nitrosomethylaniline. 17168689 - In vitro and in vivo metabolism of a gamma-secretase inhibitor bms-299897 and generatio... 1929259 - Metabolic disposition and pharmacokinetics of the antiviral agent 6-methoxypurine arabi... 2578739 - Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile... 7250299 - The influence of epsilon-aminocaproic acid on the mineralocorticoid hypertension of the... 9608009 - Tubuloglomerular feedback in dahl rats. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 177 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1991 May |
Date Detail:
|
Created Date: 1991-07-05 Completed Date: 1991-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 440-6 Citation Subset: IM |
Affiliation:
|
Department of Organic Chemistry, Indian Institute of Science, Bangalore. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biotransformation Cresols / isolation & purification, metabolism*, urine Gas Chromatography-Mass Spectrometry Male Microsomes, Liver / metabolism* Monoterpenes* Rats Rats, Inbred Strains Terpenes / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Cresols; 0/Monoterpenes; 0/Terpenes; 106-44-5/4-cresol; 494-90-6/menthofuran |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxidative modification of glycated low density lipoprotein in the presence of iron.
Next Document: Properties of a thermoactive beta-1,3-1,4-glucanase (lichenase) from Clostridium thermocellum expres...