Document Detail

Evidence of fetal C-reactive protein urinary excretion in early gestation.
MedLine Citation:
PMID:  12738102     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: C-reactive protein has been measured in amniotic fluid in the second and third trimesters of gestation, and its elevated concentration has been found to be associated with adverse pregnancy outcome. It remains unexplained whether amniotic fluid C-reactive protein is of fetal origin. CASE: We report the measurement of C-reactive protein in fetal urine obtained by transabdominal vescicocentesis in a fetus at 15 weeks' gestation affected by obstructive uropathy. Using an enzyme-linked immunosorbent assay, C-reactive protein was detected at a concentration of 234 ng/mL. CONCLUSION: The fetal kidneys excrete C-reactive protein as early as 15 weeks' gestation.
Luigi Raio; Fabio Ghezzi; Michel D Mueller; Jane McDougall; Antoine Malek
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  101     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-09     Completed Date:  2003-05-15     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1062-3     Citation Subset:  AIM; IM    
Department of Obstetrics & Gynecology, University of Berne-Inselspital, Berne, Switzerland.
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MeSH Terms
C-Reactive Protein / urine*
Fetal Diseases / diagnosis*,  urine*
Pregnancy Trimester, Second
Urinary Tract / abnormalities*
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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