Document Detail

Evidence for an enhanced fibrinolytic capacity in cirrhosis as measured with two different global fibrinolysis tests.
MedLine Citation:
PMID:  22906184     Owner:  NLM     Status:  Publisher    
Background & Objectives: It has been known for a long time that cirrhosis is associated with hyperfibrinolysis, which might contribute to an increased risk and severity of bleeding. However, recent papers have questioned the presence of a hyperfibrinolytic state in cirrhotic patients and postulated a rebalanced system due to concomitant changes in both pro- and anti-fibrinolytic factors. Therefore we re-investigated the fibrinolytic state of cirrhotic patients using two different overall tests including a recently developed test for global fibrinolytic capacity (GFC) using whole blood. Patients and Methods: Blood was collected from 30 healthy controls and 75 patients with cirrhosis of varying severity (34 Child-Pugh A, 28 Child-Pugh B and 13 Child-Pugh C). The plasma clot lysis time (CLT), which is inversely correlated with fibrinolysis, was determined as well as the GFC. Results: The mean CLT was 74.5 min in the controls and decreased significantly to 66.9 min in Child-Pugh class A patients, 59.3 min in class B patients and 61.0 min in class C patients, and hyperfibrinolysis existed in 40% of the patients. The median GFC was 1.7 μg/ml in the controls and increased significantly to 4.0 μg/ml in Child-Pugh class A patients, 11.1 μg/ml in class B patients and 22.5 μg/ml in class C patients, and hyperfibrinolysis existed in 43% of the patients. Taken together, 60% of the patients showed hyperfibrinolysis in at least one of the two global assays. Conclusion: A rebalanced fibrinolytic system may occur, but hyperfibrinolysis is found in the majority of patients with cirrhosis. © 2012 International Society on Thrombosis and Haemostasis.
Dingeman C Rijken; Edith L Kock; Ana H C Guimarães; Simone Talens; Sarwa Darwish Murad; Harry L A Janssen; Frank W G Leebeek
Related Documents :
22706254 - Plasma total homocysteine is a determinant of carotid intima-media thickness and circul...
22219614 - Apache ii score, rather than cardiac function, may predict poor prognosis in patients w...
22087164 - Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis.
21717044 - The ideal measurement of the quality of life in post stroke patients: an urban study.
17204144 - Development of a series of patient information leaflets for constipation using a range ...
23975894 - At what age is hydrocephalus detected, and what is the role of head circumference measu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
Department of Hematology and Erasmus University Medical Center, Rotterdam, the Netherlands Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Active relatives and health-related physical fitness in European adolescents: The HELENA Study.
Next Document:  "Preformed Biomarkers Including Dialkylphosphates (DAPs) in Produce May Confound Biomonitoring in Pe...