Document Detail

Evidence for an elevation in serum interleukin-2 and tumor necrosis factor-alpha levels before the clinical manifestations of preeclampsia.
MedLine Citation:
PMID:  9272206     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The purpose of this study is to clarify whether the disruption of immune regulation occurs in early pregnancy before the clinical manifestations of preeclampsia. METHOD OF STUDY: The serum concentrations of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were determined by using enzyme-linked immunoadsorbent assay (ELISA) in the first trimester of pregnancy in women who had preeclampsia develop after 28 weeks of pregnancy (preeclamptic group) and in women who completed pregnancy uneventfully (control group). RESULTS: Serum concentrations of both IL-2 and TNF-alpha in the first trimester of the preeclamptic group were significantly higher than those of the control group. CONCLUSIONS: That the perturbation of feto-maternal immune regulation may precede the clinical manifestations of preeclampsia, which may be of relevance in the development of preeclampsia, is suggested.
Y Hamai; T Fujii; T Yamashita; H Nishina; S Kozuma; Y Mikami; Y Taketani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  38     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-17     Completed Date:  1997-10-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of medicine, University of Tokyo, Japan.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Interleukin-2 / blood*
Pre-Eclampsia / blood*,  etiology,  immunology*
Pregnancy Trimester, First
Prospective Studies
Tumor Necrosis Factor-alpha / analysis*
Reg. No./Substance:
0/Interleukin-2; 0/Tumor Necrosis Factor-alpha

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