| Evidence for the efficacy of low-dose diuretic monotherapy. | |
| | |
MedLine Citation:
|
PMID: 8876475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Diuretic monotherapy has been recommended by the fifth report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (JNC-V) as a preferred initial treatment for hypertension. Thiazide diuretics are commonly used to treat hypertension because of their demonstrated efficacy, favorable safety profile, low acquisition cost, and their proven ability to reduce blood pressure-related morbidity and mortality. Once-daily low-dose hydrochlorothiazide (12.5 mg/ day) or chlorthalidone (15 mg/day) effectively reduces blood pressure in patients with stage 1 or stage 2 hypertension in comparison with placebo. Blood pressure reductions with low-dose hydrochlorothiazide and chlorthalidone are comparable to that achieved with higher doses (25 and 50 mg/day). Additional blood pressure reductions can be attained with concomitant use of once-daily low-dose hydrochlorothiazide or chlorthalidone with an angiotensin-converting enzyme (ACE) inhibitor, a beta blocker, or a calcium antagonist. Once-daily low-dose hydrochlorothiazide provides clinically meaningful blood pressure lowering while minimizing adverse effects, such as electrolyte disturbances, cholesterol elevations, and increases in serum uric acid levels. |
| | |
Authors:
|
J M Flack; W C Cushman |
Related Documents
:
|
2523645 - Improved blood pressure control with isradipine in hypertensive patients treated with p... 3890395 - Interference on metabolism induced by muzolimine and chlorthalidone in type ii hyperten... 1659495 - Comparison of the efficacy and tolerability of lisinopril and sustained-release verapam... 3926135 - Lack of effect of oral magnesium on high blood pressure: a double blind study. 7331785 - The relationship between increasing intraarticular pressures and intraosseous pressures... 7497725 - Extravasation rates and complications of intraosseous needles during gravity and pressu... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The American journal of medicine Volume: 101 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1996 Sep |
Date Detail:
|
Created Date: 1996-11-26 Completed Date: 1996-11-26 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 53S-60S Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgical Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chlorthalidone
/
administration & dosage Clinical Trials as Topic Diuretics Drug Therapy, Combination Humans Hydrochlorothiazide / administration & dosage Hypertension / drug therapy* Practice Guidelines as Topic Sodium Chloride Symporter Inhibitors / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Diuretics; 0/Sodium Chloride Symporter Inhibitors; 58-93-5/Hydrochlorothiazide; 77-36-1/Chlorthalidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The evolution of low-dose diuretic therapy: the lessons from clinical trials.
Next Document: Combination therapy with diuretics: an evolution of understanding.