| Evidence for early vessel involvement in the dysfunctional myocardium of Takayasu's arteritis. | |
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MedLine Citation:
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PMID: 11123136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 15-year-old girl presented with persistent fevers, night sweats, leukocytosis, an elevated erythrocyte sedimentation rate, and a 13-pound weight loss over 2 months. Duplex Doppler scans, computed tomographic scan, and magnetic resonance imaging studies were suggestive of Takayasu's arteritis. Left ventricular dysfunction occurred during the episode of active disease, and an endomyocardial biopsy demonstrated increased HLA-DR (human leukocyte antigen-DR) on the endothelium and evidence of immune complex deposition in the walls of small vessels. One year later, after treatment with corticosteroids and resolution of clinical symptoms, repeat endomyocardial biopsy revealed focal interstitial fibrosis and persistent immune complex deposition. These results indicate that the inflammatory, vasculitic process affecting the large vessels in Takayasu's arteritis may also involve the endomyocardium and its small vessels resulting in ventricular dysfunction. |
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Authors:
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J P Breinholt; M Tristani-Firouzi; J F Bohnsack; R E Shaddy |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric cardiology Volume: 22 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-06-07 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 74-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Primary Children's Medical Center and the University of Utah, 100 N. Medical Drive, Suite 1500, Salt Lake City, UT 84113, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aorta / pathology Aortic Arch Syndromes / complications, physiopathology Female Fluorescent Antibody Technique Heart Catheterization Humans Myocarditis / complications*, diagnosis, drug therapy Myocardium / pathology*, ultrastructure Takayasu Arteritis / complications*, diagnosis, drug therapy Ventricular Dysfunction, Left / diagnosis, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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