| Evidence of early degenerative changes in large arteries in human essential hypertension. | |
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MedLine Citation:
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PMID: 4030039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noninvasive evaluation of brachial artery diameter (pulsed Doppler velocimetry) and pulse wave velocity (strain gauge mechanography) was performed in 23 normal subjects and 49 patients with uncomplicated essential hypertension. Pulsatile arterial function was described in terms of derived characteristic impedance and arterial compliance. Compared with normal controls, hypertensive patients had greater arterial diameter (p less than 0.01) and pulse wave velocity (p less than 0.001). Two nomograms obtained from normal subjects relating the product of age and diastolic pressure to diameter and pulse wave velocity were used for analysis of the hypertensive group; 35 patients were inside the 95% confidence limits of the diameter and pulse wave velocity nomograms (Group 1), while 14 patients were outside the pulse wave velocity nomogram (Group 2). Age and mean pressure were similar, but pulse wave velocity was higher (p less than 0.001), arterial compliance lower (p less than 0.001), and characteristic impedance higher (p less than 0.001) in Group 2 than in Group 1. The amplitude of pulse pressure was higher in Group 2 than in Group 1 (p less than 0.001), and a negative correlation was found between pulse pressure and arterial compliance in Group 2, but not in Group 1. Thus, in the majority of hypertensive patients, arterial modifications could be related to the normal influence of age and pressure. In contrast, other patients exhibited features suggesting excessive arterial stiffness, manifested by abnormally high pulse wave velocity, decreased arterial compliance, and increased characteristic impedance. |
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Authors:
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A C Simon; J Levenson; J Bouthier; M E Safar; A P Avolio |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 7 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1985 Sep-Oct |
Date Detail:
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Created Date: 1985-10-10 Completed Date: 1985-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aging Arteries / pathology Arteriosclerosis / etiology Diastole Humans Hypertension / complications*, physiopathology Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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