Document Detail

Evidence of duration and type of illness in children found unexpectedly dead.
MedLine Citation:
PMID:  942235     Owner:  NLM     Status:  MEDLINE    
The thymus, rib, and liver from a series of 200 children found unexpectedly dead showed that in over 90% of these children the costochondral junction indicated that a retardation in growth velocity had preceded death. In a similar proportion of children the liver showed fatty change indicating a metabolic upset, which in 5% was of severe degree. Changes in the thymus compatible with a normal reaction to infection were observed in only a little over half of the child deaths. An absence of gross thymic reaction in some children in whom there was other evidence of infection suggests that in some an abnormal immunological reaction was taking place. It is concluded that careful systematic clinical monitoring of growth in these children would have shown abnormality in nearly all.
C Sinclair-Smith; F Dinsdale; J Emery
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  51     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  IM    
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MeSH Terms
Fatty Liver / pathology
Growth Disorders / complications*,  pathology
Liver / pathology
Ribs / pathology
Sudden Infant Death / etiology*
Thymus Gland / pathology

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