| Evidence for distinct preterm and term phenotypes of preeclampsia. | |
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MedLine Citation:
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PMID: 20482241 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine differences in maternal and fetal characteristics in pregnancies complicated by preterm versus term preeclampsia. METHODS: Using our electronic database we identified 143 women who met the American College of Obstetricians and Gynecologists criteria for preeclampsia between January 1995 and August 2003. We collected data on age, smoking status, maternal serum markers, and newborns. We compared the group delivering preterm (<37 weeks) with those delivering at term (> or =37 weeks). Analyses were based on ANOVA, Wilcoxon Rank Sum test, and chi-square test. Statistical significance was determined based on alpha = 0.05. Data are expressed as mean +/- SD unless otherwise indicated. RESULTS: Eighty women delivered preterm and 63 delivered at term. Women who delivered preterm with preeclampsia were younger, lighter, and were more likely to smoke cigarettes than those delivering at term with preeclampsia. Maternal liver enzyme concentrations were significantly greater in the preterm group. Newborn birthweight percentile (gestational age specific) was significantly lower for preterm preeclampsia. We found no significant differences in maternal platelet count, uric acid concentration, or newborn gender between groups. CONCLUSIONS: Differences exist in maternal and fetal characteristics between women who develop preterm preeclampsia and those who develop preeclampsia at term. These data support the hypothesis that multiple preeclamptic phenotypes exist. |
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Authors:
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Julie K Phillips; Mary Janowiak; Gary J Badger; Ira M Bernstein |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 622-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont, Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, Vermont, USA. julie.phillips@vtmednet.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis, blood Electronic Health Records Female Gestational Age Humans Infant, Newborn Phenotype Pre-Eclampsia / blood, classification*, epidemiology*, physiopathology Pregnancy Premature Birth* / blood, epidemiology, physiopathology Retrospective Studies Term Birth* / blood, physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL 71944/HL/NHLBI NIH HHS; R01 HL071944-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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