Document Detail

Evidence for distinct catabolic pathways of adenine ribonucleotides and deoxyribonucleotides in human T lymphoblastoid cells.
MedLine Citation:
PMID:  6334686     Owner:  NLM     Status:  MEDLINE    
The catabolisms of deoxy-ATP and ATP were compared in cultured human T lymphoblastoid cells incubated under various conditions. It was found that in the presence of deoxycoformycin, an inhibitor of adenosine deaminase, deoxyadenosine was the only product of deoxy-ATP catabolism. In contrast, the main products of ATP catabolism in either the presence or the absence of deoxycoformycin were inosine and hypoxanthine. These results demonstrate that deoxy-ATP catabolism proceeds exclusively via deoxyadenosine deamination, whereas ATP catabolism proceeds mainly via adenylate deamination. These findings thus provide an explanation for the selective deoxynucleotide metabolic abnormalities associated with adenosine deaminase deficiency in humans.
J Barankiewicz; A Cohen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  259     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-25     Completed Date:  1985-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15178-81     Citation Subset:  IM    
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MeSH Terms
Adenosine / metabolism
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Adenosine Triphosphate / metabolism*
Cell Line
Coformycin / analogs & derivatives,  pharmacology
Deoxyadenine Nucleotides / metabolism*
Hypoxanthine Phosphoribosyltransferase / deficiency
Hypoxanthines / metabolism
Inosine / metabolism
Structure-Activity Relationship
T-Lymphocytes / metabolism*
Reg. No./Substance:
0/Deoxyadenine Nucleotides; 0/Hypoxanthines; 11033-22-0/Coformycin; 1927-31-7/2'-deoxyadenosine triphosphate; 53910-25-1/Pentostatin; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 58-63-9/Inosine; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 68-94-0/Hypoxanthine; EC Phosphoribosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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