| Evidence of disrupted prepulse inhibition in unaffected siblings of bipolar disorder patients. | |
| | |
MedLine Citation:
|
PMID: 17481589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Prepulse inhibition (PPI) of the startle response refers to a reduction in the response to a strong stimulus (pulse) if preceded shortly by a weak stimulus (prepulse). Disrupted PPI is thought to reflect abnormalities in the inhibitory control of information processing. Reduced PPI has been reported in mania, although it is not clear whether it represents a trait feature of bipolar disorder (BD). To address this issue, the present study examined whether disrupted PPI is present in individuals at high risk for BD. METHODS: Twenty-one remitted BD patients and 19 of their unaffected siblings were compared with 17 age- and gender-matched healthy volunteers on tests of acoustic startle reactivity and PPI of the startle response. RESULTS: There were no group differences in startle reactivity. Compared with healthy individuals, BD patients and their unaffected siblings showed lower PPI. In the patient group, no significant correlations were found between PPI and measures of symptom and disease severity or medication. CONCLUSIONS: This is the first study to report reduced PPI in remitted BD patients and their unaffected first-degree relatives. This finding, although in need of replication, suggests that PPI disruption may represent a trait deficit in BD associated with genetic predisposition. |
| | |
Authors:
|
Stella G Giakoumaki; Panos Roussos; Maria Rogdaki; Costandina Karli; Panos Bitsios; Sophia Frangou |
Related Documents
:
|
7062299 - Schizophrenia and psychosomatic illness. 9387089 - Antidepressant-associated hypomania in outpatient depression: a 203-case study in priva... 18382119 - Increased plasma leptin in antipsychotic-naïve females with schizophrenia, but not in ... 8350789 - Phenomenological differences of hallucinations between schizophrenic patients in penang... 22310879 - Chronic sinopulmonary inflammatory diseases in adults with undetectable serum ige in in... 15469189 - Spatial and temporal parameters of gait disturbances in schizophrenic patients. 7394979 - Peyronie disease and surgical treatment: a new concept. 16477499 - Urinary dysfunction and autonomic control in amyloid neuropathy. 2157819 - Peripheral nerve functions in chronic alcoholic patients on disulfiram: a six month fol... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-03 |
Journal Detail:
|
Title: Biological psychiatry Volume: 62 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-12-06 Completed Date: 2008-02-27 Revised Date: 2008-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
|
Languages: eng Pagination: 1418-22 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Crete, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation
/
methods Adolescent Adult Analysis of Variance Bipolar Disorder / genetics*, physiopathology* Case-Control Studies Electromyography Female Habituation, Psychophysiologic Humans Inhibition (Psychology)* Male Middle Aged Siblings* / psychology Startle Reaction / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New platinum(II) complexes containing both an O,O'-chelated acetylacetonate ligand and a sulfur liga...
Next Document: Association of bipolar and substance use disorders in parents of adolescents with bipolar disorder.