Document Detail

Evidence of disrupted prepulse inhibition in unaffected siblings of bipolar disorder patients.
MedLine Citation:
PMID:  17481589     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prepulse inhibition (PPI) of the startle response refers to a reduction in the response to a strong stimulus (pulse) if preceded shortly by a weak stimulus (prepulse). Disrupted PPI is thought to reflect abnormalities in the inhibitory control of information processing. Reduced PPI has been reported in mania, although it is not clear whether it represents a trait feature of bipolar disorder (BD). To address this issue, the present study examined whether disrupted PPI is present in individuals at high risk for BD. METHODS: Twenty-one remitted BD patients and 19 of their unaffected siblings were compared with 17 age- and gender-matched healthy volunteers on tests of acoustic startle reactivity and PPI of the startle response. RESULTS: There were no group differences in startle reactivity. Compared with healthy individuals, BD patients and their unaffected siblings showed lower PPI. In the patient group, no significant correlations were found between PPI and measures of symptom and disease severity or medication. CONCLUSIONS: This is the first study to report reduced PPI in remitted BD patients and their unaffected first-degree relatives. This finding, although in need of replication, suggests that PPI disruption may represent a trait deficit in BD associated with genetic predisposition.
Stella G Giakoumaki; Panos Roussos; Maria Rogdaki; Costandina Karli; Panos Bitsios; Sophia Frangou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-03
Journal Detail:
Title:  Biological psychiatry     Volume:  62     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-27     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1418-22     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Medical School, University of Crete, Crete, Greece.
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MeSH Terms
Acoustic Stimulation / methods
Analysis of Variance
Bipolar Disorder / genetics*,  physiopathology*
Case-Control Studies
Habituation, Psychophysiologic
Inhibition (Psychology)*
Middle Aged
Siblings* / psychology
Startle Reaction / physiology*

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