| Evidence for a direct and indirect action of leucine enkephalin at the feline ileocecal sphincter. | |
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MedLine Citation:
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PMID: 2896285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An in vitro whole organ bath preparation was used to examine the effects of leucine enkephalin on the cat ileocecal sphincter (ICS) intraluminal pressure and myoelectric activity. The bath allowed separation of the bathing media surrounding the ICS and the ileum. Leucine enkephalin (2 x 10(-7) M) when added to the ileal bathing medium caused a delayed increase in ICS spike activity and pressure which was blocked by tetrodotoxin (10(-5)M). In contrast, leucine enkephalin (2 x 10(-7)M) added directly to the ICS bathing medium caused an immediate spike-associated contractile response which was tetrodotoxin-resistant. Thus both an indirect and direct opiate action at the ICS was demonstrated. |
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Authors:
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G Bertiger; A Ouyang; J C Reynolds; S Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 42 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-06-03 Completed Date: 1988-06-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1697-703 Citation Subset: IM |
Affiliation:
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Dept. of Medicine, University of Pennsylvania, Philadelphia 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Bethanechol Bethanechol Compounds / pharmacology Cats Electric Stimulation Enkephalin, Leucine / pharmacology* Ileocecal Valve / drug effects*, physiology Muscle Contraction / drug effects Pressure Tetrodotoxin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AM 19379-10/AM/NIADDK NIH HHS; AM 34148-03/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bethanechol Compounds; 4368-28-9/Tetrodotoxin; 58822-25-6/Enkephalin, Leucine; 674-38-4/Bethanechol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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