Document Detail


Evidence for a detrimental relationship between hypertension history, prospective memory, and prefrontal cortex white matter in cognitively normal older adults.
MedLine Citation:
PMID:  23389652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension affects many older adults and is associated with impaired neural and cognitive functioning. We investigated whether a history of hypertension was associated with impairments to prospective memory, which refers to the ability to remember to perform delayed intentions, such as remembering to take medication. Thirty-two cognitively normal older adult participants with or without a history of hypertension (self-reported) performed two laboratory prospective memory tasks, one that relied more strongly on executive control (nonfocal prospective memory) and one that relied more strongly on spontaneous memory retrieval processes (focal prospective memory). We observed hypertension-related impairments for nonfocal, but not focal, prospective memory. To complement our behavioral approach, we conducted a retrospective analysis of available structural magnetic resonance imaging data. Lower white matter volume estimates in the anterior prefrontal cortex were associated with lower nonfocal prospective memory and with a history of hypertension. A history of hypertension may be associated with worsened executive control and lower prefrontal white matter volume. The translational implication is that individuals who must remember to take antihypertensive medications and to monitor their blood pressure at home may be impaired in the executive control process that helps to support these prospective memory behaviors.
Authors:
Michael K Scullin; Brian A Gordon; Jill Talley Shelton; Ji Hae Lee; Denise Head; Mark A McDaniel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cognitive, affective & behavioral neuroscience     Volume:  13     ISSN:  1531-135X     ISO Abbreviation:  Cogn Affect Behav Neurosci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-10-30     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101083946     Medline TA:  Cogn Affect Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Analysis of Variance
Cognition Disorders / complications*
Dementia / complications*
Female
Humans
Hypertension / complications*
Longitudinal Studies
Magnetic Resonance Imaging
Male
Memory, Episodic*
Middle Aged
Nerve Fibers, Myelinated / pathology*
Neuropsychological Tests
Prefrontal Cortex / pathology*
Semantics
Grant Support
ID/Acronym/Agency:
F32 AG041543/AG/NIA NIH HHS; F32AG041543/AG/NIA NIH HHS; P01 AG003991/AG/NIA NIH HHS; P01AG03991/AG/NIA NIH HHS; P50AG05681/AG/NIA NIH HHS; T32 AG000030/AG/NIA NIH HHS; T32AG00030/AG/NIA NIH HHS
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