| Evidence of dependence of lipoprotein(a) on triglyceride and high-density lipoprotein metabolism. | |
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MedLine Citation:
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PMID: 22264571 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lipoprotein(a) [Lp(a)] is a complex lipoprotein consisting of a low-density lipoprotein (LDL)-like ApoB(100)-containing core particle covalently bound to apo(a), a large functionally complex glycoprotein. The mechanisms of Lp(a) metabolism and its interactions with cell-surface lipoprotein receptors are incompletely understood. In this study, we investigated the relationship of Lp(a) to other lipoproteins at high and normal levels of serum triglycerides (TGs). We measured serum lipid and Lp(a) particle concentrations in 148 unselected primary- and secondary-prevention patients. Subjects with TG > 200 mg/dL were classified as having high TG in accordance with National Cholesterol Education Program Adult Treatment Panel III guidelines. Our analysis revealed mean TG levels of 100 and 270 mg/dL in the normal and high TG groups, respectively. Lp(a)-C, Lp(a)-P, and Lp(a) cholesterol content per particle [Lp(a)-C/Lp(a)-P] did not differ between groups. At normal TG levels, stepwise multiple linear regression revealed that Lp(a)-P correlated with Lp(a)-C (P < 10(-6)), ApoAI (P = .0001), the high-density lipoprotein cholesterol subfraction ratio (HDL(2)-C/HDL(3)-C; P = .002), and dense very-low-density lipoprotein cholesterol (VLDL(3)-C; P = .04), overall model R = 0.74. At high TG levels, Lp(a)-P very strongly correlated primarily with HDL(2)-C/HDL(3)-C and TG-related variables with minimal dependence on Lp(a)-C (P = .09), overall model R = 0.96. These findings provide evidence of shared metabolic mechanisms for Lp(a), HDL, TG, and very low-density lipoprotein at high serum TG. Future studies are needed to elucidate common mechanisms, enzymes, and receptors involved in Lp(a) and HDL/TG metabolism with a focus on how these mechanisms are modified in the setting of hypertriglyceridemia. |
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Authors:
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Matthew Konerman; Krishnaji Kulkarni; Peter P Toth; Steven R Jones |
Publication Detail:
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Type: Journal Article Date: 2011-09-13 |
Journal Detail:
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Title: Journal of clinical lipidology Volume: 6 ISSN: 1933-2874 ISO Abbreviation: J Clin Lipidol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300157 Medline TA: J Clin Lipidol Country: United States |
Other Details:
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Languages: eng Pagination: 27-32 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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