Document Detail

Evidence for a deficiency of interferon response in mononuclear cells from hepatitis C viremic patients.
MedLine Citation:
PMID:  9288599     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The pathophysiology of chronic hepatitis C and the mechanisms of resistance to interferon alpha are poorly understood. The aim of this work was to assess the influence of HCV infection and the viral genotype on lymphocyte production of 2',5' oligo-adenylate synthetase activity and monocyte production of TNF alpha and IL1 beta. METHODS: Mononuclear cells from 50 consecutive patients were studied after 6 months of interferon treatment. Patients with persistent viremia (PCR-positive, elevated ALT, n = 39) were compared with the PCR-negative patients with normal ALT activity (n = 11) of similar age and sex ratio. RESULTS: Cells from the viremic patients showed lower basal and stimulated 2',5' oligo-adenylate synthetase activity, and a lower in vitro response capacity to human recombinant interferon. In contrast, no difference was observed in basal and stimulated TNF alpha or IL1 beta production between the two groups. In the PCR-positive patients the viral genotype had no significant influence on the response of mononuclear cells to interferon or endotoxin. CONCLUSIONS: These results show that the presence of HCV in blood is associated with an elective defect in interferon system activation, independently of the viral genotype.
P Podevin; J Guechot; L Serfaty; L Monrand-Joubert; C Veyrunes; M T Bonnefis; R Poupon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  27     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
INSERM U402, Laboratoire de biochimie A, Hôpital Saint-Antoine, Paris, France.
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MeSH Terms
2',5'-Oligoadenylate Synthetase / metabolism
Antiviral Agents / pharmacology*
Cells, Cultured
Cytokines / biosynthesis
Hepacivirus / genetics
Hepatitis C / metabolism*,  pathology*
Interferons / pharmacology*
Monocytes / drug effects*,  metabolism
Recombinant Proteins / pharmacology*
Reference Values
Viremia / metabolism*,  pathology*
Reg. No./Substance:
0/Antiviral Agents; 0/Cytokines; 0/Recombinant Proteins; 9008-11-1/Interferons; EC 2.7.7.-/2',5'-Oligoadenylate Synthetase

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