Document Detail

Evidence for a defective inhibition of pentagastrin-stimulated gastric acid secretion by antral distension in the duodenal ulcer patient.
MedLine Citation:
PMID:  680489     Owner:  NLM     Status:  MEDLINE    
Graded antrum distension by 50-, 100-, and 150-ml balloon volumes significantly stimulated gastric acid secretion in 6 duodenal ulcer patients, but had no stimulatory effect in 6 healthy subjects. Antrum distension by 150-ml balloon volume had no effect on the acid response to submaximal stimulation by a continuous intravenous infusion of pentagastrin in the duodenal ulcer patients, but significantly inhibited this response in the healthy subjects. The inhibition by antrum distension in the healthy subjects amounted to 20%. The results suggest that antrum distension elicits stimulatory as well as inhibitory mechanisms in man with inhibition of acid secretion predominating in healthy subjects and stimulation of acid secretion predominating in duodenal ulcer patients. The mechanism of inhibition is unknown.
I M Schöön; S Bergegårdh; U Grötzinger; L Olbe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  75     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  AIM; IM    
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MeSH Terms
Duodenal Ulcer / physiopathology*
Gastric Juice / secretion*
Middle Aged
Pentagastrin / administration & dosage*
Pyloric Antrum / physiopathology*
Stimulation, Chemical
Reg. No./Substance:

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