| Evidence for a decreased noradrenaline sensitivity in mesenteric resistance vessels from rats with chemical renal medullectomy. | |
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MedLine Citation:
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PMID: 2766656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Chemical renal medullectomy was performed in Wistar rats by intraperitoneal injection of 2-bromoethylamine hydrobromide (200 mg/kg body weight). The effect of this treatment upon blood pressure and mesenteric vascular reactivity and morphology was studied 3 weeks after treatment. 2. Blood pressure was significantly raised in medullectomized rats. The indirect systolic pressures (means +/- SEM) were 112 +/- 2.4 mmHg (14.9 +/- 0.32 kPa) and 123 +/- 3.5 mmHg (16.4 +/- 0.5 kPa) (P less than 0.02) for control (n = 12) and medullectomized (n = 12) rats, respectively. However, there were no significant changes in the morphology of the mesenteric resistance vessels. 3. Maximum pressor responses and Ca2+ sensitivities were unchanged in these vessels compared with controls, but the sensitivity to noradrenaline was significantly reduced. Noradrenaline pD2 (= -log ED50) values (means +/- SEM) were 5.87 +/- 0.03 and 5.69 +/- 0.08 (P less than 0.05) for control (n = 12) and medullectomized (n = 12) rats, respectively. 4. This study demonstrates that in this model of hypertension the noradrenaline sensitivity is reduced in mesenteric resistance vessels, but there are no detectable morphological changes associated with the rise in blood pressure. |
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Authors:
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S J Bund; A M Heagerty; A Fletcher; J D Swales |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 77 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-27 Completed Date: 1989-09-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 167-70 Citation Subset: IM |
Affiliation:
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Department of Medicine, Leicester Royal Infirmary, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ethylamines Female Hypertension / chemically induced, physiopathology* Kidney Medulla / drug effects* Mesenteric Arteries / drug effects* Norepinephrine / pharmacology* Rats Rats, Inbred Strains Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Ethylamines; 107-09-5/2-bromoethylamine; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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