Document Detail

Evidence of de novo collagen synthesis in healing human gastric ulcers.
MedLine Citation:
PMID:  7569756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The fibrillar collagens, types I and III, have been demonstrated in healthy human gastric mucosa as well as in the submucosa of gastric ulcer edges, where they are remarkably increased. METHODS: To verify the occurrence and activity of de novo collagen synthesis, we examined gastric biopsy specimens from six patients with antral ulcers and six normal controls. By means of in situ hybridization, using a 35S-labeled RNA probe, we could localize the specific procollagen mRNA for type-I collagen. RESULTS: In normal gastric mucosa this mRNA was expressed by only a very limited number of cells, whereas at the ulcer edges the specific signal could be demonstrated in a large number of submucosal cells. CONCLUSION: These results suggest a substantial role of fibroneogenesis in the process of gastric ulcer healing.
A Gillessen; M Shahin; T Pohle; E Foerster; T H Krieg; W Domschke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  30     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-25     Completed Date:  1995-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  515-8     Citation Subset:  IM    
Dept. of Medicine B, University of Münster, Germany.
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MeSH Terms
Collagen / analysis,  biosynthesis*
Gastric Mucosa / metabolism*,  pathology,  ultrastructure
In Situ Hybridization / methods
Middle Aged
Procollagen / analysis,  biosynthesis
RNA, Messenger / analysis
Stomach Ulcer / metabolism*,  pathology
Wound Healing / physiology*
Reg. No./Substance:
0/Procollagen; 0/RNA, Messenger; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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