Document Detail


Evidence for cyclic GMP in the yeast Saccharomyces cerevisiae, and studies on its possible role in growth.
MedLine Citation:
PMID:  2844029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The yeast Saccharomyces cerevisiae is shown to be equipped with cyclic GMP, the level of which ranges from 6 pmol/10(9) cells with pressed baker's yeast to 21 pmol/10(9) cells with exponentially growing cells. In extracts from synchronized growing yeast, cyclic GMP increases stepwise, being doubled at the time of each mitosis. Theophylline and 3-isobutyl-1-methylxanthine induce a rapid increase of cyclic GMP, followed by a premature formation of the septal cell wall between mother cell and bud. The effects of 3-isobutyl-1-methylxanthine are reversible. Dibutyryl-cyclic GMP, and, after a pronounced lag, also dibutyryl-cyclic AMP, induce a premature cell division, too. Cholera toxin induces premature cell divisions without a preceding increase in cyclic GMP. Neither theophylline nor 3-isobutyl-1-methylxanthine, cholera toxin or one of the dibutyryl-cyclic nucleotides modify the growth rate of the culture. None of the agents has significant effects on the level of cyclic AMP. The results suggest that cyclic GMP possibly controls an early step of mitosis, whereas ADP-ribosylation might govern a subsequent event.
Authors:
H Eckstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  43     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    1988 May-Jun
Date Detail:
Created Date:  1988-10-17     Completed Date:  1988-10-17     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  386-96     Citation Subset:  IM    
Affiliation:
Institut für Physiologische Chemie der Universität, Hamburg, Bundesrepublik Deutschland.
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MeSH Terms
Descriptor/Qualifier:
3',5'-Cyclic-GMP Phosphodiesterases / metabolism
Cyclic AMP / metabolism
Cyclic GMP / isolation & purification,  metabolism,  physiology*
DNA, Fungal / metabolism
Kinetics
Saccharomyces cerevisiae / drug effects,  growth & development*
Theophylline / pharmacology
Chemical
Reg. No./Substance:
0/DNA, Fungal; 58-55-9/Theophylline; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; EC 3.1.4.35/3',5'-Cyclic-GMP Phosphodiesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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