| Evidence for a critical role of panretinal pathophysiology in experimental ROP. | |
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MedLine Citation:
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PMID: 19506927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review, we summarize our in vivo studies of retinal pathophysiology in experimental models of retinopathy of prematurity, which were largely focused on the temporal and spatial links between retinal neovascularization (NV), vascular oxygenation, and intraretinal ion regulation. These studies were made possible through the use of magnetic resonance methods. Prior to the phenotype change from normal vessel development to NV, we found little support for a pathogenic role of focal retinal hypoxia at the border of vascular and avascular retina. However, key links were found between retinal NV and functional panretinal defects in both oxygenation to a provocation and intraretinal ion regulation. Through a treatment which reduced NV incidence but not panretinal pathophysiology, proliferative disease was found to last longer than that in the untreated group. These considerations provide compelling evidence that clinical attention directed toward reducing retinal NV should include approaches that reduce functional panretinal pathophysiology. |
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Authors:
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Bruce A Berkowitz; Robin Roberts |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-06-09 |
Journal Detail:
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Title: Documenta ophthalmologica. Advances in ophthalmology Volume: 120 ISSN: 1573-2622 ISO Abbreviation: Doc Ophthalmol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370667 Medline TA: Doc Ophthalmol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 13-24 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA. baberko@med.wayne.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal* Humans Infant, Newborn Magnetic Resonance Imaging Oxygen / physiology Rats Retina / physiopathology* Retinal Neovascularization / physiopathology Retinopathy of Prematurity / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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EY018109/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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