| Evidence for compartmentation of uridine nucleotide pools in rat hepatoma cells. | |
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MedLine Citation:
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PMID: 570061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interaction between the de novo and salvage pathways of pyrimidine metabolism was studied in a line of rat hepatoma cells by co-labelling with [14C]-uridine and [3H]orotate. A difference in the ratio of 14C/3H between CTP and UTP in acid-soluble nucleotide pool was reflected in the corresponding ratios in CMP and UMP in RNA, with uridine labelling cytidine nucleotides relatively more effectively than orotate. These results are not compatible with the concept of a single UTP pool, and a new model for pyrimidine anabolic pathways, based on compartmentation of de novo from salvage pathways, is proposed. |
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Authors:
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M J Losman; E H Harley |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 521 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 762-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cytidine Monophosphate / metabolism Liver Neoplasms, Experimental / metabolism* Orotic Acid / metabolism RNA, Neoplasm / metabolism Uracil Nucleotides / metabolism* Uridine Monophosphate / metabolism |
| Chemical | |
Reg. No./Substance:
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0/RNA, Neoplasm; 0/Uracil Nucleotides; 58-97-9/Uridine Monophosphate; 63-37-6/Cytidine Monophosphate; 65-86-1/Orotic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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